Thermodynamic Recognition of Polar Guests by CD Derivatives

Binding selectivities can be increased by polar interactions, e.g., Coulomb interactions or hydrogen bonds, between functional groups of CD derivatives and functional groups at the guest. Recently, we demonstrated the superior binding properties of hepta-6-5-6-deoxy- i-CD derivatives towards the cancer treatment dmg camptothecin [47], 

Functional group Number of functional groups -AG°/kJ mof1 for cationic guestb —AG°/kJ mol-1 for anionic guestc 

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