Thermodynamic properties hydrolytic reactions

Reactions of cisplatin and its hydrolytes with longer-chain amino acids +NH3(CH2)nC02 are less relevant to the biological properties of platinum because these compounds are less abundant in vivo. The six- and seven-membered chelate rings formed with /3-alanine (n = 2) and y-aminobutyric acid (n = 3) are progressively less stable kinetically and thermodynamically than the five-membered A/, 0-chelate ring formed with glycine [3]. 

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