Thermodynamic cycle-perturbation approach

Reddy RM, Varney MD, Kalish V, Viswanadhan VN, Appelt K. Calculation of relative differences in the binding free energies of HIV-1 protease a thermodynamic cycle perturbation approach. J. Med. Chem. 1994 37 1145-1152. 

Calculation of Relative Differences in the Binding Free Energies of HFVl Protease Inhibitors A Thermodynamic Cycle Perturbation Approach. 

Reddy, M.R., Viswanadhan, V.N., and Weinstein, J.N. 1991. Relative differences in the binding free energies of human immunodeficiency virus 1 protease inhibitors A thermodynamic cycle-perturbation approach. Proc. Natl. Acad. Sci., 88,10287-10291. 

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