Thermal Properties, Crystallinity, and Phase Behavior of Polyanhydrides

Characterization of Thermal Properties, Crystallinity, and Phase Behavior of Polyanhydrides 

It is important to characterize the thermal properties of polyanhydrides that are proposed for drug delivery applications, as changes in crystallinity 

The branched aromatic polyanhydrides synthesized by Sanders et al. (1999 Mathiowitz et al., 1990b) demonstrated lower Tgs than the corresponding P(PCPP-SA) copolymers. The para-xylyl polymers synthesized by Anastasiou and Uhrich (2000a) (Pp-o-CPX and Pp-m-CPX) had systematically higher Tgs than the ortho-isomers (Po-o-CPX, Pm-o-CPX, P/uo-CPX). 

Staubli et al. (1991) offer an in depth analysis of the effects of sequence distribution on the Tg of poly(anhydride-co-imide)s and discuss the experimental results with respect to several applicable theoretical models 

The change in melting point and glass transition of the copolymers as a function of copolymer composition are also of particular interest because this reveals information about the copolymer microstructure. This is discussed along with the crystallinity characterization in the following section. 

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