Therapeutic area screening

Kinases remain a highly pursued drug target for numerous therapeutic areas [95]. In addition to the primary screen, selectivity profiling of... 

Pfizer s search for new treatments spans hundreds of research projects across multiple therapeutic areas—more than any other company. Our scientists, clinicians, technicians, and other professionals employ state-of-the-art tools ranging from robotic high-throughput screening (a method pioneered by Pfizer) to sophisticated genomic studies, to deliver a steady stream ofinnovative new products that enhance human and animal health. 

Despite the extensive use of ADME-PK screens in drug discovery, there is no one correct or standardized workflow for drug discovery. Often, ADME screening strategies are dictated by specific needs of the discovery program (i.e., therapeutic area, competitive landscape), recent precedent (i.e., success, failure), and/or the chemistry and disposition of a series of lead compounds. 

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