Theaflavins apoptosis induced

Certain natural compounds possess anti-apoptotic effects. For example, ascorbic acid and a-tocopherol prevent apoptosis caused by serum withdrawal in HL-60 cells with the antioxidative effects (76). Caffeic acid inhibits ceramide-induced apoptosis in U937 cells through the inhibition of protein tyrosine kinase activity 17). Quercetin inhibits hydrogen peroxide-induced apoptosis via intervention in the activator protein 1 (AP-1) -mediated apoptotic pathway 18). Epigallocatechin-3-gallate and theaflavins inhibits arsenite-induced apoptosis through the decrease in phosphorylation of Erks and JNKs (79). Therefore, it is important to know whether these natural compounds show inhibitory effects on Trp-P-1-induced apoptosis. In this study, we demonstrated that Trp-P-1 induced caspase-8-initiated apoptosis in rat MNCs, and that certain food components inhibited Trp-P-l-induced apoptosis. 

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