The Snyder solvent classification scheme

The Snyder solvent classification scheme (29, 30) that has been successfully applied to LC systems (31-37) for LC separation optimization appears to be a general framework that can be used for guidance in the selection of the modifier. Some preliminary experiments have been done to determine the applicability of this approach to SFC systems as a prelude to a more in-depth, statistically-designed modifier selection study. These first experiments are the topic of this paper the basis of the proposed modifier selection scheme will now be described in detail. 

The purpose of these first experiments in the modifier survey work was to determine the applicability of the Snyder solvent classification scheme to the choice of modifier to see if an in-depth study would be warranted. The experimental conditions are described in the final section of this paper. 

---