The Search for Efflux Inhibitors

Other possibilities for interfering with MDR transporters include targeting the assembly of the pump components and blocking the TolC-like tunnel. At present, these are purely hypothetical. There are no reports of molecules with such activity. 

The structural elucidation of efflux pumps will undoubtedly facilitate the future search and optimization of EPIs. It will also help clarify the mode of action of EPIs identified in the past using more traditional approaches. However, higher resolution 

---