The Probability of Molecular Interactions

Achieving enantiomeric discrimination requires understanding the interactions between the selector and the selectand. In his Ph.D. thesis [19], Feibush postulated that attaining an enantiomeric separation on a chromatographic chiral system required that certain conditions should exist  

This model can also be extended to enantiomeric separation using liquid chromatography. 

The solvation energy of one enantiomer in the active chiral phase can be described as the contribution of all possible forms of solvent/solute associates. These associates are in equilibrium with fast interconversion rates. Each form contributes to the total free energy according to its particular formation energy and its particular molar fraction [25,26]. These complexes between the selector and selectand should also be as mutually exclusive as possible, to prevent a given interaction from occurring at multiple sites in the diastere-omeric complexes [5]. 

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