The Mukaiyama Synthesis

The Mukaiyama synthesis was published in full in 1999 (278), after various preliminary reports (439,440, 447).This synthesis was unique in that the B-ring was formed first, leading to a B BC ABC ABCD 

The bioactivity and mechanism of action of taxol has been extensively investigated, but since this review is targeted to a chemical audience this section will focus primarily on chemical aspects of its 

It should also be pointed out that taxol and its analogs have been found to have other effects besides their anticancer activity. Thus Georg and her colleagues have reported taxol s activity in protecting against 

---