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The Metabolism of Benzene in Man and Mammals

The initial step of the oxidation of benzene to the epoxide has been widely studied (see [196, 217, 219, 220]) It is the reaction mediated by a mixed-function oxidase [196, 2i9] in the NADPH/NADP-system of the microsomes [220]. Cytochrome P-450, NADPH-reductase and phosphatide are important factors [Pg.143]

Central nervous system reflex changes, insomnia [Pg.144]

Bone marrow haematoxic affections. chromosomal aberrations [Pg.144]


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