The mechanics of remodeling

The process of nucleosome remodeling, with the exception of that mediated by RNA polymerase II [111], often leads to the displacement of the histone octamer from one segment of the DNA to another. For the ISWI and dMi-2 containing complexes transfer only in cis, but not in trans has been observed [48]. 

The major alternative mechanism for nucleosome redistribution to the bulge propagation mechanism is twist diffusion. Supporting this, it is clear that the nucleosome core particle is capable of accommodating alterations to DNA twist of 1-2 bp per double helical turn without significant changes to the 

Sc soil DEt LCKT PLSTlt DEGH RLILTGTPLt RAGGLGLNL RAKRIGQ 

Dm iSMi CQIOLOKT PKSTLQ DEXH RLLITOTPI RAOGLGIUL MMRIGQ 

Dm Mi-3 DEHOL KT PLSTLQ DEXH RLLLTOTPIjQW RAGGDGINL MNRIGQ 

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