The Ionic Theory of Cell Potential by Hodgkin, Huxley, and Katz

The Ionic Theory of Cell Potential by Hodgkin, Huxley, and Katz 

It was then that Hodgkin and Katz made the important discovery that the magnitude of this overshoot is quantitatively related to the logarithm of the external Na concentration. This discovery led to the formulation of the ionic theory of cell potentials described by the Hodgkin-Katz equation, following a prior formulation of Goldman. 

In the meanwhile, the temporal sequence of events underlying an action potential was investigated by Hodgkin and Huxley with the aid of the voltage clamp technique. These studies led to an extension of the ionic theory to include a theory of the action potential based on the 

---