The Inhibition of Monoamine Uptake by Antidepressants

Note 0 = no side effect + = minor side effect ++ = moderate side effect +++ = major side effect. 

Amlodipine is a calcium-channel-blocking agent, which is indicated in the treatment of hypertension, chronic stable angina, and vasospastic (Prinzmetal or variant) angina. The ten Ca2+ channel antagonists that are in chnical use in the 

United States have diverse chemical structures. Five classes of compounds have been examined phenylalkylamines, dihy-dropyridines, benzothiazepines, diphenylpiperazines, and a diarylaminopropylamine. At present, verapamil (a phenyl-alkylamine) diltiazem (abenzothiazepine) nifedipine, amlo-dipine, felodipine, isradipine, nicardipine, nisoldipine, and nimodipine (dihydropyridines) and bepridil (a diarylaminopropylamine ether used only for refractory angina) are approved for clinical use in the United States. 

Isradipine also produces the typical peripheral vasodilation seen with other dihydropyridines, but because of its inhibitory effect on the SA node, little or no rise in heart rate is seen. This inhibitory effect does not extend to the cardiac myocytes, however, because no cardiodepressant effect is seen. Despite the negative chronotropic effect, 

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The Inhibition of Monoamine Uptake by Antidepressant Inhibition of Reuptake... 

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