The formation of oestradiol from testosterone and its physiological significance

7 The formation of oestradiol from testosterone and its physiological significance 

Testosterone is an intermediate in the biosynthesis of oestradiol. The conversion, which involves three successive hydroxylations and the loss of a methyl group, is catalysed by the enzyme aromatase. Aromatase has three catalytic activities 19-hydroxylase, 19-hydroxysteroid dehydrogenase and 

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