The Drug Guru Project

Kent D. Stewart, Jason Shanley, Karam B. Alsayyed Ahmed, and J. Phillip Bowen 

BioisosUres in Medicinal Chemistry, First Edition. Edited by Nathan Brown 

Encoding the transformations made use of technology provided by Daylight Chemical Information Systems, Inc. (www.daylight.com). While most medicinal chemists are commonly aware of the SMILES (Simplified Molecular Input line Entry System) code created by Daylight, less familiar is their SMIRKS system for encoding transformations of one SMARTS pattern into another SMARTS pattern. Key to the 

---

The concept of bioisosterism is central to the Drug Guru project and is fully described in the other chapters of this book. Many of the rules included in the 530... 

Summary The Abbott Experience with the Drug Guru Project 1197... 

---