The Concept of Immune Complex Disease

With respect to studies in animal models which dissect the mechanisms of formation, localization, and fate of immune complexes, the mechanisms by which they elicit an inflammatory response, and their biologic activities, we provide little more than summary information required to understand the concept of immune complex disease and the principles of the tests. For more detailed information, the reader is referred to several excellent reviews (C14, H2, Til, Ul, W12). 

Uptake by mononuclear phagocytic system (Reticuloendothelial system) 

Schematic of immune complex formation, elimination, and deposition. 

Properties of the complex Nature of the antigen Quantity available for reaction Number of determinants (epitopes) per molecule Size 

Nature of the antibody Quantity Affinity Class (isotype) 

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