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The calculation of tmax and Cmax

The calculation of tmax and Cmax for a drug normally starts from the relevant [Pg.176]

Once /max has been calculated Cmax can be found by substitution of the appropriate values of F, VA, D0, kab and /ce) for the drug in Equation (8.30). Since F and Vd are constants Cmax is proportional to the dose administered the larger the dose the greater Cmax. [Pg.176]




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