The Bunyavirus Genus and Its Role in Encephalitis

In general, the California encephalitis subgroup viruses spread from the site of inoculation to skeletal muscles, which is the major site of replication. The virus then spreads to the lymphatic channels, thus spreading to additional skeletal muscles and cardiac muscles. Ultimately, the virus ends up in the CNS, where viral replication can occur in neurons and glial cells. Due to considerable neuronal necrosis, death can 

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