The Building-Block Approach

The most important categories of complexes used as metalloligands are oxalato-complexes, cyano-complexes, and bisoxamidato complexes. Let s discuss several representative examples from each category. 

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A Generalized Design Approach to Power Supplies Introducing the Building-block Approach to Power Supply Design... 

The Building-block Approach to PWM Switching Power Supply Design 26... 

I 74 The Building-block Approach to Understanding Main-group-metal Complex Structures... 

While parallel synthesis of arrays of glycopeptides is readily achieved by implementation of the building-block approach (Scheme 14.1, Strategy 2),101 glycopeptide library synthesis in a combinatorial manner via the split-mix method has yet to prove routine. The difficulty lies in the structural analysis of the vast number of compounds generated in picomolar quantities on a single bead. Whereas peptides on... 

Scheme 14.1 Strategies for glycopeptide library synthesis Strategy 1 chemical or enzymatic glycosylation of peptide or glycopeptide Strategy 2 the building-block approach. While enzymes have not yet been used in the solid-phase synthesis of glycopeptide libraries, several resin-bound glycopeptides have been glycosylated enzymatically.36,114...

A comparison of direct O-mannosylation of serine or threonine on resin-bound peptides, with the incorporation of mannosylated serine or threonine building blocks, resulted in a higher overall yield for the building block approach (12.5 vs 5% for direct condensation). 134 Later it was demonstrated that resin-bound peptides are able to be glycosylated with different glycosyl trichloroacetimidates without protection of the hydroxy groups of the oligosaccharide moiety (Section 6.3.2.8). 135,136 ... 

Scheme 31 Examples of Glycopeptide Synthesis by the Building Block Approach in SolutionI315 5101 OAc...

Scheme 32 Example of Glvcopeptide vSynthesis by the Building Block Approach on vSolid Phase 5" ... 

This chapter does not attempt to cover electrochemical processes which involve the insertion of a group already containing carbon-fluorine bonds into an existing molecule (the building block approach), e.g., perfluoroalkyl group insertion via the Kolbe reaction, or fluoroacyloxylations or fluoroalkoxylations via electro-oxidation, or fluoroalkylation via electro-reduction. These have been reviewed elsewhere [1,2]. 

Consistent with the building block approach, countries are free to determine which of the... 

Following the building-block approach, artificial glycopeptides were synthesized by Wong et al. [40], as small-molecule mimics of sialyl Lewis . They utilized the fucosylated amino acid (9-allyl carboxylic ester building block (Scheme 14.21). The properly protected, threonine... 

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