Thalictrum cultratum

Thalictrum cultratum Wall. (Ranunculaceae) was the source of 0-methylthalmine (61), C3gH42N206, [< ] >5 -25° (c 0.26, MeOH), previously known as a derivative of thalmine (62). Structure proof was by comparison of NMR data with literature values and by complete NOEDS study (539). 

Isolation and Identification of Quaternary Alkaloids from the Roots of Thalictrum cultratum Wall. (Ranunculaceae) - Part I. Isolation and Identification of Alkaloids from the Roots and Stems of Pycnarrhena manillensis Vidal. (Menispermaceae) -Part II., by MC Lin, 263 pp., University of Pittsburgh, 1987 [19]... 

The first part of this dissertation documents the isolation and identification of seven quaternary alkaloids from extracts of the roots of Thalictrum cultratum Wall., including six protoberberines (berberine, columbamine, jatrorrhizine, palmatine, (+)-thalidastine, and thalifendine) and one aporphine (magnoflorine). This research resulted in one publication [20]. 

Thalictrum cultratum Wall. (Ranunculaceae)[241] Thalictrum faberi Ulbr. (Ranunculaceae)[242,243]... 

There are four alkaloids that constitute this small subgroup. The mono imine [N(2 )] alkaloids thalmethine (98) and O-methylthalmethine (96) have only been isolated from Thalictrum species (Ranunculaceae), with the former reported as a constituent of T. minus, while the latter has been found in T. minus, T. minus var. minus, and T. revolutum. These two alkaloids differ at C(12), where thalmethine is monophenolic. A third N(2 ) imine alkaloid is thalsivasine (380), a constituent of Thalictrum cultratum and Thalictrum minus var. minus. This alkaloid is monophenolic at C(7), instead of C(12). The final alkaloid of this small group is the secobisbenzylisoquinoline alkaloid revolutionone (266) which has only been isolated from Thalictrum revolutum (Ranunculaceae). The alkaloids of this small subgroup appear to be restricted in distribution to the genus Thalictrum. 

Thalidasine (100) analogs include N-desmethylthalidasine (190) and thalidasine-2a-N-oxide (377). Thalidasine has been isolated from no less than fourteen species of the genus Thalictrum (including T. cultratum and T. faberi), while N-desmethylthalidasine (196) has been isolated only from Thalictrum cultratum and T faberi. The N-oxide has been isolated from just one plant, T. cultratum. Thalrugosinone (224), the N(2)-formyl derivative of thalidasine, has... 

There are only two alkaloids that comprise Type Xlla, 5-hydroxythalidasine (311) and 5-hydroxythalidasine-2a-N-oxide (312). These two bases have the stereochemistry and have only been found to date in Thalictrum cultratum. 

The two alkaloids of this very small subgroup are methoxylated at C(5), C(12), and C(7 ), differing only by being phenolic [S-Hydroxythalmine (6-demethylthalmiculine)(313)] or methoxylated [thalmiculine (383)] at C(6). Both bases are tertiary amines with N-methyl functions, and both alkaloids have only been isolated from Thalictrum cultratum (Ranunculaceae). 

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