Tfc4 and Other Pol III Factors

Tfc4 also binds other components of the Pol III transcription apparatus, although a requirement for the TPR arrays and, in particular, specific residues in the TPR channels has been reported for only some of these interactions. 

understanding the complex mechanism by which Tfc4 interacts with TFIIIB subunits may provide a paradigm for understanding how multiple TPR arrays contribute to the assembly and function of multisubunit complexes. 

Shodai, T., Muto, T., Mihara, K., Torii, H., Nishikawa, S., Endo, T., and Kohda, D. (2000). Structural basis of presequence recognition by the mitochondrial protein import receptor Tom20. Cell 100, 551-560. 

Andrau, J. C., Sentenac, A., and Werner, M. (1999). Mutagenesis of yeast TFIIIB70 reveals C-terminal residues critical for interaction with TBP and C34. J. Mol. Biol. 288, 511-520. 

Gabrielsen, O., and Hall, B. D. (1986). Effects of tRNATyr point mutations on the binding of yeast RNA polymerase III transcription factor C. J. Biol. Chem. 261, 5275-5282. 

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