Tetrodotoxin binding

Duch DS, Levinson SR (1987) Neurotoxin-modulated uptake of sodium by highly purified preparations of the electroplax tetrodotoxin-binding glycopeptide reconstituted into lipid vesicles. J Membrane Biol 98 43-55 Duch DS, Recio-Pinto E, Frenkel C, Levinson SR, Urban BW (1989) Veratridine modification of the purified sodium channel a-polypeptide from eel electroplax. J Gen Physiol 94 813-831... 

Henderson R, Wang J (1972) Solubilization of a specific tetrodotoxin binding component from garfish olfactory nerve membrane. Biochemistry 11 4565-4569 Hille B (1967) A pharmacological analysis of the ionic channels in nerve. Thesis, Rockefeller University. University Microfilms International, Ann Arbor, no 689584 Hille B (1971) The permeability of the sodium channel to organic cations in myelinated nerve. J Gen Physiol 58 599-619... 

Matsui, T., Yamamori, K., Furukawa, K., Kono, M., 2000. Purification and some properties of a tetrodotoxin binding protein from the blood plasma of Kusafiigu, Takiftigu niphoblos. Toxicon, 38 463 168. 

Shiomi, K., Yamaguchi, S., Kikuchi, T., Yamamori, K., and Matsui, T. 1992. Occurrence of tetrodotoxin-binding high molecular weight substances in the body fluid of shore crab. Hemi-grapsus sanguineus. Toxicon 30, 1529-1537. 

W. Aimers and R. Levinson, Tetrodotoxin binding to normal and depolarized frog muscle and the conductance of a single sodium channel, J. Physiol. (London) 247, 483 (1975). 

Solubilisation of the tetrodotoxin-binding component of neural membranes, believed to be at least part of the voltage-dependent sodium channel, has been achieved. However, the material is so unstable that no biophysical studies have been made with this material [40]. 

R. Henderson and J. H. Wang, Solubilization of a Specific Tetrodotoxin-Binding Component from Garfish Olfactory Nerve Membrane, Biochemistry 11, 4565-4569 (1972). 

W. S. Agnew, S. R. Levinson, J. S. Brabson, and M. A. Raftery, Purification of the Tetrodotoxin-Binding Component Associated with the Voltage-Sensitive Sodium Channel from Electrophorus electricus Electroplax Membranes, Proc. Natl Acad. Scl U A 75, 2606-2610 (1978). 

Penzotti JL, Fozzard HA, Lipkind GM, Dudley SC Jr (1998) Differences in saxitoxin and tetrodotoxin binding revealed by mutagenesis of the Na + channel outer vestibule. Biophys J 75 2647-2657... 

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