Tetrazolo pyrimidines, thermolysis

A kinetic study of thermolysis reactions of TV-crotyl substituted 1,2,4-triazoles was performed at temperatures in the range of 260-350 CC <00JHC1135>. Thermolysis of tetrazolo[l, 5- >]pyridazines, tetrazolo[l,5-a]pyrimidines and tetrazolo[l,5-a]pyridines allowed easy ring contraction to a facile preparation of cyanopyrazole heterocycles . 

Wentrup and co-workers have carried out systematic flash vacuum thermolysis studies with a series of fused tetrazoles. Investigations of the isomeric tetrazolo[l,5- ]pyrazine 17 and tetrazolo[l,5-f]pyrimidine 20 showed that, in both cases, ring contraction takes place to afford imidazoles in high yields, but isotope labeling experiments revealed that the mechanisms of the openings of the two ring systems are different <2002JOC8538>. 

Tetrazolo[l,5-c]pyrimidine, 8-amino-7-chloro-purine synthesis from, 5, 591 Tetrazolopyrimidines purine synthesis from, 5, 591 Tetrazolo[ 1,5-a]pyrimidines cycloaddition reactions, 5, 881 reactions, 5, 880 ring opening, 5, 880 structure, 5, 859, 860 synthesis, 5, 902 thermolysis, 5, 881 Tetrazolo[ 1,5-c]pyrimidines hydrogenation, 5, 881 reactions, 5, 881 structure, 5, 859, 860 synthesis, 5, 902 thermolysis, 5, 881... 

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