Tetramethylammonium hydroxide solubilization

G. Tao, S. N. Willie, R. E. Sturgeon, Determination of inorganic mercury in biological tissues by cold vapor atomic absorption spectrometry following tetramethylammonium hydroxide solubilization, J. Anal. Atom. Spectrom., 14 (1999), 1929D1931. 

J. B. B. da Silva, D. L. G. Borges, M. A. M. S. da Veiga, A. J. Curtius, B. Welz, Determination of cadmium in biological samples solubilized with tetramethylammonium hydroxide by electrothermal atomic absorption spectrometry, using ruthenium as permanent modiPer, Talanta, 60 (2003), 977 D 982. 

H. Matusiewicz, B. Golik, Determination of major and trace elements in biological materials by microwave induced plasma optical emission spectrometry (MIP-OES) following tetramethylammonium hydroxide (TMAH) solubilization, Microchem. J., 76 (2004), 23 D29. 

Preliminary Comments The most popular protocol for organometallic contaminant species is based on the solubilization of a tissue in strongly alkaline media, for example, tetramethylammonium hydroxide. An aliquot of the solution is diluted with water and analyzed after derivatization. The tissue solubilization procedure can be considerably accelerated by carrying it out in a microwave (MW) Feld [9]. 

Tissues can be solubilized by tetramethylammonium hydroxide (TMAH). Murphy et al. (M8) prepared rat liver and kidney homoge-... 

M8. Murphy, L., Menden, E. E., Eller, P. M., and Petering, H. G., Atomic absorption determination of zinc, copper, cadmium, and lead in tissues solubilized by aqueous tetramethylammonium hydroxide. Anal. Biochem. 53, 365-372 (1973). 

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