TetraMe-BITIOP

Scheme 8.7 Hydrogenations of olefins with tetraMe-BITIOP.

In 2000, these authors also developed a very efficient diphosphine-bithiophene ligand, tetraMe-BITIOP, which is depicted in Scheme 8.29. The ruthenium complex of this electron-rich diphosphine was used as the catalyst in asymmetric hydrogenation reactions of prostereogenic carbonyl functions of a-... 

On the other hand, the asymmetric allylation of aldehydes was also successfully performed in the presence of chiral easily available biheteroaromatic diphosphine oxides, such as tetraMe-BITIOPO, which is the precursor of the industrially produced tetraMe-BITIOP. Using this organocatalyst, the reaction afforded homoallyllic alcohols in fair-to-good yields and with enantio-selectivities of up to 95% ee, as shown in Scheme 2.50. 

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