Tetrahydroisoquinolines structure-activity relationships

Matter, H., Schudok, M., Schwab, W., Thorwart, W., Barrier, D., Billen, G., Haase, B., Neises, B., Weithmann, K., WOLLMANN, T. Tetrahydroisoquinoline-3-carboxylate based matrix-metalloproteinase inhibitors design, synthesis and structure-activity relationship. Bioorg. Med. Chem. 2002, 10(11), 3529-3544. 

Tetrahydroisoquinoline-3-carboxylate based matrix metalloproteinase inhibitors design, synthesis and structure-activity relationship. Bioorg. Med. Chem. 2002, 10, 3529-3544. 

Renaud J, Bischoff SF, Buhl T, Floersheim P, Fournier B, Geiser M, Halleux C, Kallen J, Keller H, Ramage P. Selective estrogen receptor modulators with conformationally restricted side chains Synthesis and structure-activity relationship of ERalpha-selective tetrahydroisoquinoline ligands. J Med Chem 2005 48 364-79. 

Renaud, J., Bischoff S.F., Buhl, T., Floersheim, P., Fournier, B., Halleux, C., Kallen, J., Keller, H. et al. (2003) Estrogen receptor modulators identification and structure-activity relationships of potent ERa-selective tetrahydroisoquinoline ligands. Journal of Medicinal Chemistry, 46, 2945-2957. 

Grunewald, G. L, Dahanukar, V. H., Jalluri, R. K., Ctiscione, K. R. Synthesis, biochemical evaluation and classical and three-dimensional quantitative structure-activity relationship studies of 7-substituted-l,2,3,4-tetrahydroisoquinolines and their relative affinities toward phenylethanolamine iV-methyltransferase and the 012-adrenoreceptor. J. Med. Chem. 1999, 42, 118-134. 

Discovery and structure-activity relationships of substituted tetrahydroisoquinoline as liver X receptor (LXR) agonists... 

The syntheses of l-(3,4-dihydroxybenzyl)-2-propyl-l,23,4-tetrahydroisoquinoline (18) and l-(4-hydroxybenzyl)-2-propyl-l,2,3,4-tetrahydroisoquinoline (19) were carried out in order to examine the structure-activity relationships when the rigid aporphine ring system is replaced by the more flexible benzyltetrahydroisoquinoline moiety which still contained all of the necessary substituents of the potent NPA molecule (4b) (Neumeyer et al. 1977). 

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