Tetrahydrobenzo pyrrolo

Several tetra- and pentacyclic systems were prepared from Pro, which was first -substituted with naphthalene or phenanthrene rings whereupon the cyclization took place. Such reactions were used for synthetic ap-proaehes toward alkaloids vinceten from Cynachum vincetoxicum (the tetrahydrobenzo /]pyrrolo[l,2-Z ]isoquinoline system 146) (79LA1212 84AJC819) or tylophorine (65T2573). 

The asymmetric 3 + 2-cycloaddition of cyclic azomethine ylides with Oppolzer s acryloyl camphor sultam has been used for the construction of X-azabicyclo[7M.2.1] alkenes in optically pure form. The non-stereospeciflc 1,3-dipolar cycloaddition of electron-poor azomethine ylides and electron-rich enamines proceeds by a two-step mechanism via zwitterionic intermediates. The 1,3-dipolar cycloaddition of 4,6-diazaphenanthrene 6-phenacylide with a variety of dienophiles readily produces the fused heterocycles tetrahydrobenzo[/]pyrrolo[l,2-/z][l,7]naphthyridines. Sequential... 

A two-step route to tetrahydrobenzo[b]pyrrolo[3,4-e][l,4]diazepinone 241 (X = NH) starting from 4-hydroxy pyrrolone 240 has been reported (Scheme 51 (1991KFZ16)). 

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