Tetrahexylammonium chloride

Serum Zn 2-(5-Bromo-2-pyridylazo)-5-(A/-propyl-ZV-sulfopropyl amino) phenol -i-tetrahexylammonium chloride 9 SP (Solvent sublation)... 

Molteni found that nitrilimine 94, generated in situ from hydrazonoyl chloride 93, reacted with electron-poor dipolarophiles (i.e. ethylacrylate in Scheme 5.24) to give pyrazo-lines in water under basic conditions and in the presence of tetrahexylammonium chloride. The presence of surfactant reduced the formation of the by-product 1,2,4,5-tetrazine derivative coming from the dimerization of 94. On the basis of a computational study, the authors conclude that the water has a rather small effect on the cycloaddition with respect to that played by the surfactant. 

The final analytical method for the simultaneous determination of A9-THC and its metabolites consists of the following sequence the cannabinoids are extracted from plasma with toluene they are then back extracted from toluene into Claisen s alkali the Claisen s alkali is diluted with water, tetrahexyl ammonium hydroxide is added and the alkaline solution is extracted with methylene chloride containing ethyl iodide. The overall recoveries were 45% for A9-THC and 83% for 11-hydroxy-A9-THC. External standards (l-0-ethyl-A9-THC and l-0-ethyl-ll-hydroxy-A9-THC) were added to the methylene chloride phase followed by a small amount of Florosil, which absorbed the tetra-hexylammonium hydroxide and tetrahexylammonium iodide. The methylene chloride was decanted and evaporated. 

Tetrahexylammonium phthalimide, generated in situ from potassium phthalimide and tetra-hcxylammonium bromide, aminates the racemic 3-(acyloxy)cycloalkenes 9 to imides (S)-10 with extremely high enantioselectivity in the presence of a palladium(0) complex prepared from dimeric n-allylpalladium chloride and the chiral ligand (/ ,/ )-G78. (5)-10c has been converted to a protected derivative of (S)-2-aminopimelic acid. 

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