Testicular toxicity inhibin

Dere, E., L. M. Anderson, M. Coulson, B. S. McIntyre, K. Boekelheide, and R. E. Chapin (2013). SOT symposium highlight translatable indicators of testicular toxicity inhibin B, MicroRNAs, and sperm signatures. Toxicol Sci 136(2) 265-273. 

A large array of parameters is available for macaques for the evaluation of effects on male and female fertility (Tables 18.2 and 18.3). Most of these parameters correspond to clinical endpoints used by gynecologists and andrologists for diagnosis of infertility. For the marmoset the number of established fertility parameters is less comprehensive than for macaques (Tables 18.2 and 18.3). However, those parameters that are available for marmosets are considered sufficient to detect clear-cut effects on male and female fertility. Most important, no assays for the determination of inhibins are available for marmosets. This is unfortunate as inhibin B does represent a good marker for testicular toxicity [32] and inhibins are useful as markers of ovarian function [33],... 

Cellular debris in the epididymis or in ejaculated semen can also signal testicular toxicity impacting gametogenesis. Measurements of circulating steroids and LH/FSH as well as inhibin B (a peptide hormone produced by Sertoli or granulosa cells) can also help characterize impacts on the reproductive system and sometimes lead to hypotheses about the underlying mechanism(s) of the alterations. 

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