Tert-butyl 4-methyl-3,5 -dioxohexanoate

Furthermore, tert-butyl 4-methyl-3,5-dioxohexanoate was regio- and enantio-selectively reduced via dynamic kinetic resolution using LBADH as catalyst to give an almost enantio-merically and diastereomerically pure ferf-butyl (4S,5R)-5-hydroxy-4-methyl-3-oxohexano-ate (Figure 7.23) [70]. 

Figure 7.23 Selective reduction of tert-butyl 4-methyl-3,5-dioxohexanoate with LBADH...

Ji, A., Wolberg, M., Wandrey, C. et al. (2001) Dynamic kinetic resolution of tert-butyl 4-methyl-3,5-dioxohexanoate through enzymatic reduction. Chemical Communications (Cambridge) (1), 57-58. 

---