2,3 6 3 "-terpyridine scaffold

Bohlmann-Rahtz method has also been applied in the solution-phase synthesis of a library of functionalized pyridine scaffold as well as the preparation of a 2,3 6 3"-terpyridine scaffold as an a-helix mimetic. ... 

Recent work involves the use of a 2,2 6,2" terpyridine scaffold with a metal center and pendant guanidinium groupsJ A dye displacement assay was employed in the determination of binding affinities for amino acids to the cavity of 30. The receptor was selective for aspartate with an affinity 1.5 x 10 M in 1 1 water/methanol. Studies with the control host in which the guanidinium groups are absent indicate that the selectivity for aspartate is due to the interactions with the Zn(II) center and the guanidinium moieties. 

Figure 10.8 shows the example ofa ruthenium(ii) bis-terpyridine complex that acts as the scaffold for a biscarboxylate recognition site 22 [62]. 

Platinum(ii)-containing complexes with inherently chiral binaphthol derivatives display a versatile scaffold between random coils and singleturn helical strands, in which the conformational transition is controlled by the Pt... Pt and n-n interactions of allq7nylplatinum(ii) terpyridine moiety upon solvent and temperature modulation. ... 

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