Ternary Systems Involving Bile Salts

Fontell studied the solubilization of n-decanol by NaDC (38). His phase diagram is redrawn in Fig. 55 and demonstrates that bile salt in adequate quantities produces a single liquid phase extending from pure water to pure decanol. Thus, bile salt not only solubilizes decanol in an aqueous solution (left side) but also solubilizes water in a decanol solution (right side). 

Monoglyceride, bile salt, and water have also been studied (10). Bile salt was shown to be an effective agent to solubilize monoglyceride. Liquid crystals were noted but not examined for type or structure. 

The NaC-lecithin-water system described above is very similar to the conjugated bile salt-lecithin-water system. Minor differences are discussed in (4). 

Bile salts also solubilize other phospholipids extensively, although no phase diagrams have been published. 

then a hexagonal phase (zone III), and finally a micellar phase (zone IV). As NaC is added to sodium oleate, the lamellar phase (zone I) disappears abruptly, showing that very little bile salt can be incorporated into the lamellar liquid crystalline phase formed by sodium oleate. At low concentrations of water, a viscous isotropic phase having a cubic lattice by X ray is present (zone II). There is a large zone of hexagonal liquid crystalline phase (zone III) which can contain up to 65% NaC by weight. This phase has been studied by X-ray diffraction at a constant 40 % water, and the distance between 

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