Terf-butyl hypochlorite

Spray solution 1 terf-Butyl hypochlorite solution. 

The halogenation reaction appears to be quite rapid therefore the time of stirring is not critical but probably should not be prolonged beyond 4 hours. The submitters used this time interval to prepare the sodium methoxide solution, and the actual time lapse depended upon the time required to prepare this solution. The solution of N,N-dichloro-a-phenylethylamine should be clear yellow after the stirring period. A turbid solution or one containing a precipitate usually indicates a poor sample of terf-butyl hypochlorite. 

Similarly to AVal derivatives, ALeu methyl ester was prepared from Leu methyl ester in 90% yield using terf-butyl hypochlorite as the chlorinating reagent and DBU as the base for dehydrochlorination. A number of peptides have been prepared using this approach.124-2X1 The other method reported by Shin et al.1841 involves a one-pot procedure using N-carboxy-Z-a, 3-didehydroleucine anhydride 61 (ALeu-NCA) to give 62 (Scheme 21) 129 841 a ANCA can also be used to prepare Alle derivatives.1841... 

The amine hydrogens of polyfluonnated anilines can be replaced with chlorine by using terf-butyl hypochlorite [65,66]... 

If the terf-butyl hypochlorite has been prepared in advance and if the methanol to be used has been allowed to reflux over magnesium overnight, the solvents can be distilled and the reaction carried to this point in an 8-hour day. However, it may be preferable to prepare the dry solvents the day before the reaction is to be run. The latter procedure appears to have little effect on the final yield provided that the solvents are stored in tightly sealed containers and transferred with due care. 

See terf-Butyl hypochlorite Butyl mbber, Naphtha... 

O—(9-terf-Butyl hydrogen monoperoxymaleate, 3010 terf-Butyl hypochlorite, 1637... 

Problem 4.34 Hydrocarbons are monochlorinated with terf-butyl hypochlorite, t-BuOCl. 

ChIoroanthracene has been prepared by the action of chlorine, terf-butyl hypochlorite, l,3-dichloro-S,S-dimethylhy-dantoin, or phosphorus pentachloride on anthracene. 

Oxidation of 3-acyl-4-hydroxy-2H-l,2-benzothiazine 1,1-dioxide (9) in methanol by silver carbonate or terf-butyl hypochlorite produced 3-methoxy-4H-l,2-benzothiazin-4-one 1,1-dioxide (35),32 apparently by a free radical mechanism with participation of solvent. 

H-l,2,4-Triazole-3,5-dione, 4-phenyl- (8,9) (4233-33-4) terf-Butyl hypochlorite Hypochlorous acid, tert-butyl ester (8) Hypochlorous acid, 1,1-dimethylethyl ester (9) (507-40-4)... 

Phenylurazole, from 4-phenyl-l-car-bethoxysemicarbazide and potassium hydroxide, 51,122 with terf-butyl hypochlorite to give... 

Preparative Methods the title sulfonimidoyl chloride (1) is prepared by the reaction of the corresponding sulfinamide with terf-butyl hypochlorite in dichloromethane at —78 °C (eq 1). Simple evaporation of the solvent and excess hypochlorite produces a reagent of sufficient quality for most current applications. The reagent can be generated and used in situ. 

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