Terf-Butoxy group

The terf-butoxy group was chosen as the protective group for the formation of p-hydroxy benzaldehyde [29]. 

Large alkoxy groups also provide steric stabilization. For example, tri-ferf-butoxysilanol, obtained by hydrolysis of sodium tri-terf-butoxy-silanolate, can be vacuum distilled without decomposition (8). 

The alkoxycarbonyl protecting groups can also be introduced into amines by, triazolides (Table 4—7). With A-tert-butoxycarbonyl-1,2,4-triazole the tert-butoxy-carbonyl protecting group (Boc) is transferred readily onto amino functions of primary amines, trimethylbenzyl ammonium salts of amino acids, or peptides.[ 1965 Alternatively, the Boc group can be transferred with terf-butylphenylcarbonate in the presence of 1,2,4-triazole. In this latter approach the triazolide is presumably formed as an intermediate. ... 

Alkyl radicals can be obtained by abstraction of a hydrogen atom from an alkyl group by another radical. This method was utilized for the generation of benzyl radicals from toluene with tert-butoxy radical obtained on heating di-terf-butyl peroxide.38 Benzoyl92 and carboxymethyl88 radicals have also been obtained by this method. The reaction gives rise to a complex mixture of products and therefore is of rather limited use. 

When isomerization of the double bond of the intermediate cyclopropene into the exo methylene position is energetically unfavored, double elimination followed by double addition of base can occur. Thus, reaction of (cu/tra i )-l,l-dichloro-2-methyl-3-vinylcyclopropane (9) with potassium terf-butoxide plus methoxide in dimethyl sulfoxide gave a mixture of cis- and trans-, -dimethoxy-2-methyl-3-vinylcyclopropane (10). Both double bonds formed via elimination appear to be conjugated with the vinyl group and do not migrate to the exo position. The similar reaction of l,l-dichloro-2-[( )-propenyl]cyclopropane (11) gave a small amount of 1-/ert-butoxy-2-(prop-2-enylidene)cyclopropane (13) in addition to products of double addition. Without added methoxide, 13 was the only product isolated. ... 

Many types of peroxides (R-O-O-R ) are also utilized, including diacyl peroxides, peroxydicarbonates, peroxyesters, dialkyl peroxides, and inorganic peroxides such as persulfate, the latter being used mainly in water-based systems. The rate of peroxide decomposition as well as the subsequent reaction pathway is greatly affected by the nature of the peroxide chemical structure, as illustrated for fert-butyl peroxyesters in Scheme 4.2. Pathway (a), the formation of an acyloxy and an alkoxy radical via single bond scission, is favored for structures in which the carbon atom in the a-position to the carbonyl group is primary (for example, terf-butyl peroxyace-tate, R = CHg). Pathway (b), concerted two-bond scission, occurs for secondary and tertiary peroxyesters (for example, terf-butyl peroxypivalate, R = C(CH3)3) [1, 2]. The tert-butoxy radical formed in both pathways may decompose to acetone and a methyl radical, or abstract a hydrogen atom to form tert-butanol. 

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