Tcell activation signals

Fig. 11.12 Overview of signaling pathways associated with activation of lymphocytes. The triggering signal for activation of T lymphocytes is generally antigen binding to the Tcell receptor. The activated receptor passes the signal on to associated tyrosine kinases like Fyn, Lck and ZAP70. These phospho-rylate the transmembrane protein LAT on cytoplasmic tyrosine residues. The LAT phospho-tyro-sine residues are docking sites for adaptors ( She,...

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