Tazarotene ethyl 6-2- 4,4-dimethylthiochroman-6-yl -ethynyl nicotinate, 5, Tazarac, Avage and Zorac Allergan

Tazarotene (ethyl 6-[2-(4,4-dimethylthiochroman-6-yl)-ethynyl] nicotinate, 5, Tazarac , Avage and Zorac Allergan) 

Adapalene (6-[3-(l-adamantyl)-4-methoxyphenyl]-2-naphthoic acid, 6, DifFerin Calderma Laboratories) 

Adapalene (6) is a naphthoic acid derivative with a methoxyphenyl adamant side-chain and is a commonly used antiacne drug [74]. Similar to the adion of tazarotene in its hydrolyzed form, tazarotenic acid, adapalene interacts seledively with RARP and RARy, and its activity on proliferation and differentiation can be blocked by a RARy antagonist [75]. In addition, adapalene has antiinflammatory potential due to its anti-API adivity [75]. Although its efficacy is similar to that of other retinoids, it has an improved therapeutic ratio due to its better tolerance (reviewed in Ref. [76]). 

Bexarotene (4-[l-(5,6,7,8-tetrahydro-3,5,58,8-pentamethyl-2-naphthalenyl)ethenyl] benzoic acid, 7) 

Bexarotene (7, Targretin ) is a seledive RXR agonist (classified as a rexinoid) whose exad mechanism of action in cancer therapy and chemoprevention is poorly 

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