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Taxol Analogs with Polymeric Acyl Substitutions

Taxol Analogs with Polymeric Acyl Substitutions [Pg.140]

The concept of linking taxol to a water-soluble polymer to improve its solubility and possibly also its pharmacokinetics has been investigated by several groups. Thus Greenwald et al. prepared 2 -(polyethyl-eneglycol) esters of taxol as potential prodrugs (366, 367), and similar compounds were also prepared by Li and his colleagues (368). The 2 - [Pg.140]

Taxol Analogs with Polymeric Acyl Substitutions. 140... [Pg.54]

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Acyl substitution

Polymerization substitution

Polymerization, substituted

Polymerization, with

Taxol

Taxol, analogs

Taxols