Taurocholate formation, inhibition

Bile salts Sodium deoxycholate Sodium glycocholate Sodium taurocholate Formation of reverse micelles, solubilization of proteins/peptides Removal of epithelial cells and formation of transient pores Inhibition of proteolytic activity Reduction of mucus viscosity... 

Bile salt export pump (BSEP gene symbol ABCB11) mediates the biliary excretion of nonconjugated bile salts, such as taurocholic acid, glycocholic acid and cholic acid, and therefore is responsible for the formation of the bile acid-dependent bile flow [97, 98]. Its hereditary defect results in the acquisition of PFIC2, a potentially lethal disease which requires liver transplantation [17, 81, 82, 99]. As discussed in Section 12.5.2, the inhibition of BSEP following drug administration may result in cholestasis. 

The specificity of the inhibitory effect of bile acids on bile acid formation has been studied by Danielsson [110]. Taurocholic acid, taurochenodeoxycholic acid and taurodeoxycholic acid, fed at the 1% level in the diet for 3-7 days, were found to inhibit cholesterol 7a-hydroxylase activity. Feeding taurohyodeoxycholic acid and... 

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