Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Targeting capabilities

A common application for (strept)avidin-biotin chemistry is in immunoassays. The specificity of antibody molecules provides the targeting capability to recognize and bind particular antigen molecules. If there are biotin labels on the antibody, it creates multiple sites for the binding of (strept)avidin. If (strept)avidin is in turn labeled with an enzyme, fluorophore, etc., then a very sensitive antigen detection system is created. The potential for more than one labeled (strept)avidin to become attached to each antibody through its multiple biotinylation sites is the key to dramatic increases in assay sensitivity over that obtained through the use of antibodies directly labeled with a detectable tag. [Pg.902]

Recently, more work has been done to increase the overall transfection efficiency with much higher targeting capability and reproducibility of the liposomal delivery system (159, 178, 179). Intravenously administered lipid/DNA complex avidly reacts with blood components. So, it is necessary to keep the complex intact in the blood until it reaches the organ of interest. Sakurai et al. (180) have... [Pg.663]

See other pages where Targeting capabilities is mentioned: [Pg.50]    [Pg.498]    [Pg.824]    [Pg.879]    [Pg.14]    [Pg.82]    [Pg.119]    [Pg.132]    [Pg.204]    [Pg.60]    [Pg.385]    [Pg.514]    [Pg.569]    [Pg.259]    [Pg.579]    [Pg.131]    [Pg.140]    [Pg.378]    [Pg.418]    [Pg.271]    [Pg.117]    [Pg.40]    [Pg.365]    [Pg.494]    [Pg.549]    [Pg.519]    [Pg.864]    [Pg.117]    [Pg.5]    [Pg.292]    [Pg.378]    [Pg.345]    [Pg.355]    [Pg.361]    [Pg.519]    [Pg.3]    [Pg.4]    [Pg.283]    [Pg.309]    [Pg.39]    [Pg.156]    [Pg.139]    [Pg.123]    [Pg.187]    [Pg.223]    [Pg.248]    [Pg.444]   
See also in sourсe #XX -- [ Pg.102 ]



SEARCH



© 2024 chempedia.info