Targeted mutant

Simon et al. [92] investigated a biocatalytic anode based on lactate oxidation by lactate dehydrogenase (LDH). The anodic current is generated by the oxidation of NADH (produced by NAD+ and substrate) while LDH catalyzes the electro-oxidation of lactate into pyruvate. As previously mentioned, the oxidation of NADH at bare electrodes requires a large overpotential, so these authors used poly(aniline) films doped with polyanions to catalyze NADH oxidation. Subsequent research by this group focused on targeting mutants of LDH that are amenable to immobilization on the polyaniline surface [93],... 

Chapter 8 / Targeting Mutant EGFR in Lung Cancer... 

The equipment and experimental procedures used to generate targeted mutant mice are described in laboratory handbooks by Joyner (1993) and Wassarman and De Pamphilis (1993). 

Jeong H et al (2009) Acetylation targets mutant huntingtin to autophagosomes for degradation. Cell 137(l) 60-72... 

Chung, D. H., Ohashi, K., Watanabe, M., Miyasaka, N., and Hirosawa, S. (2000). Mannose trimming targets mutant a2-plasmin inhibitor for degradation by the proteasome. J. Biol. Chem. 275, 4981-4987. 

Zhao, M., GeUer, J., Ma, H., Yang, M., Penman, S., Hoffman, R.M., 2007. Monotherapy with a tumor-targeting mutant of Salmonella typhimurium cures orthotopic metastatic mouse models of human prostate cancer. Proc. Natl. Acad. Sci. 104, 10170-10174. 

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