Targeted Multistep Synthesis from Sucrose

Hydrolysis of sucrose in acidic 2-chloroethanol provided the corresponding glycoside, basic cyclization of which furnished a spiro derivative.15,300 

Disaccharides analogous to sucrose, but having different rings might have useful biological properties. Galactosucrose was obtained by a multistep sequence from sucrose in 27% overall yield.235 An enzymatic route to this derivative, involving the fructosyltransferase (FTF) from Bacillus subtilis NCIMB 

Regioselective silylation of sucrose afforded the 6 -protected derivative, which was fully benzylated and then deprotected at the 6 -position, and further 

Functionalization of sucrose molecule can be also performed regioselectively at any of the terminal positions C-F or C-6, or C- with the secondary 

Benzylation of l,6,6 -tri-0-tritylsucrose afforded the fully protected derivative from which the trityl protecting groups were removed under controlled acidic 

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