Targeted Design and Open-Ended Discovery

Targeted design builds on the foundation of previous curiosity-driven discoveries, but its progress also drives the need for new fundamental understanding. To view the technological developments that grow from open-ended research 

The targeted design approach is beginning to be used in the IT community. Examples are available that are built on several decades of real success in computer science and in pure and applied mathematics  

The use of targeted design to bring IT resources to bear on problems in chemical science and technology is likely to become more widespread. That approach would provide progress for virtually every point identified earlier in this chapter. Many of the applications require capacity computing—linked with robust, reli- 

Many of the resuits that we have been able to find, we have found can be achieved by the judicious use of small empirical corrections or simpie extrapoiation schemes. I think that was already evident from your presentation. So i feel there is a slight danger in saying that you can oniy achieve this high a level of accuracy by using massive resources. 

John A. Pople, Northwestern University (comments following presentation by Thom Dunning, Appendix D) 

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