Target-Ligand Complexes

Studying target-ligand interactions analyzing intact target-ligand complexes by MS... 

Two diverse target-ligand complexes were taken as examples. The shape frequency distributions obtained from positive MIF for the complexes lad-DME [11] and Ixli-GLT [12] are compared, as shown in Fig. 5.9. Both target (lad) and ligand... 

Uptake of protein by hepatocytes can occur via one of two mechanisms (a) receptor-mediated en-docytosis or (b) non-selective pinocytosis, again with subsequent protein proteolysis. Similarly, a proportion of some proteins are likely degraded within the target tissue, as binding to their functional cell surface receptors triggers endocytotic internalization of the receptor ligand complex (Figure 4.7). 

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