Target identification scheme

In 1984 Munzenberg et al. reported the results of experiments to produce element 108 by bombardment of ° Pb targets with Fe ions in the Unilac [105]. Three atoms of 108 (Table 13.9) were identified through their correlated alpha decay chains using the same experimental set-up and identification schemes as in previous experiments to produce element 107, described in Section 13.9. 

In 1982, Munzenberg and co-workers reported the observation of one correlated alpha decay event during the irradiation of Bi targets with Fe ions in the Unilac, which was interpreted as resulting from the production and decay of 266109 [101] (Table 13.9). The experimental set-up and isotope identification scheme were similar to those used in their experiments to produce element 107 described in Section 13.9. One high-energy alpha decay, 11.10 MeV, occurred at... 

Deoxycytidine (dCyd) (14 in Scheme 2) is also an excellent target for one-electron oxidation reactions mediated by triplet excited menadione. On the basis of extensive identification of dCyd photooxidation products, it was concluded that this nucleoside decomposes by competitive hydration and deprotonation reactions of cytosine radical cations with yields of 52% and 40%, respectively [53]. It was also found, on the basis of 180 labeling experiments, that hydration of cytosine radical cations (15) predominantly occurs... 

The result of a standard photoaffinity experiment can provide an output in three levels [8] as shown in Scheme 2. The photolytically induced targeted introduction of a (radio )label onto the target biopolymer helps to identify any specific binding proteins (first level of identification) responsible for a particular action in the signaling cascade or to identify the binding domain within the target protein (second level of identification) or allows one to identify the amino acid sequence of the binding protein (third level of identification). 

Fig. 1. Scheme for RNA aptamer identification targeting cocaine-binding sites on the nicotinic acetylcholine receptor (nAchR). 

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