Target family-specific

The number of records in total, as well as the number of unique compounds and targets, is highly relevant. Both the diversity of target classes and the big target families need to be taken into account. This breadth and depth comes specifically from the scope and number of scientific journals and patents that are covered within the database. For these sources, the age of the annotation needs to be taken into account. It is also very important that especially human targets are covered. 

Estrogen receptors are part of the family of nuclear receptors that share many common properties. In fact, in addition to ligand-induced specific changes of the ER structure (Brzozowski et al., 1997), target-cell specific factors play a major role in determining the final conformation of the ER-ligand complex and the response achieved. 

If the CB[n] family is to supplant the cyclodextrins as the platform of choice for basic and applied studies of molecular recognition, then a series of additional developments must take place, many of which involve the development of new synthetic procedures. First, improved methods for the separation of crude CB[n] mixture on the laboratory (i.e., up to 1 kg) to industrial (i.e., tonnes) scale must be developed. Alternatively, synthetic procedures that selectively target a specific CB[n] (e.g., CB[8] or CB[10]) would be tremendously valuable. Second, the development of high-yielding methods of functionalizing pre-formed CB[n] - particularly for CB[7], CB[8], and CB[10] - would have a dramatic impact on the field. Third, a deficiency of the CB[n] family relative to the cyclodextrins is that they are inherently achiral, which... 

One of the most extensively studied families of peptide toxins, the conotoxins, is isolated from marine cone snails.140 141 Each snail produces a suite of 100-200 peptides in its venom, which is used for the capture of prey, and given that more than 500 species of cone snails are thought to exist, conotoxins represent an enormous diversity of peptide toxins. They have been classified into families, based on their target receptor specificity, and superfamilies, according to their... 

---