Tangeretin structure

Figure 1 Chemical structure of polyphenolics in citrus. (A) Bergamottin, (B) 6 7 dihydroxybergamottin, (C) Naringenin, (D) Naringin, (E) Rutin, (F) Tangeretin, and (G) Nobiletin.

Chemical structures of flavonoids. These flavonoids consisted of three groups flavone (apigenin and lutolin), flavonols (flavonol, kaempferol, quercetin, myricetin, tangeretin, and nobiletin) and isoflavones (daizein, genistein, biochanin A, and equol). 

Hirano et al. [18] have shown an apoptotic cell death-inducing activity of tangeretin using HL-60 cells. PMFs, including nobiletin and tangeretin, had previously been reported to induce differentiation of mouse myeloid leukemia cells [19]. From the results of structure-activity relationship studies, Kawaii et al. [19] concluded that the hydroxyl group at the 3-position and the methoxyl group at the 8-position enhanced the... 

Flavones have a close structural relationship to the flavonols, but unlike flavonols they are not widely distributed in plants. The only significant occurrences in plants are in celery, parsley, and a few other herbs, and they predominantly occur as 7-0-glycosides (e.g., luteolin and apigenin). In addition, polymethoxylated flavones have been found in citrus fruits (e.g., nobiletin and tangeretin). 

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