Talinolol Erythromycin

P-gp (ABCB1) Verapamil, digoxin, mitoxantrone, vinblastine, doxorubicin, losartan, talinolol, cortisol, dexamethasone, colchicine, loperamide, domperidone, indinavir, erythromycin, tetracycline, itraconazole, cyclosporine, methotrexate, amitryptyline, phenobarbital, morphine, cimetidine, and others... 

Schwarz, U. I., Gramatte, T., Krappweis, J., Oertel, R., Kirch, W., P-glycoprotein inhibitor erythromycin increases oral bioavailability of talinolol in humans, Int. J. Clin. Pharmacol. Ther. 2000, 38, 161-167. 

The serum levels of talinolol and possibly nadolol are increased by erythromycin, but the clinical importance of this is uncertain. Te-lithromycin does not appear to adversely affect sotalol-induced QT prolongation. However, the combined use of sotalol and intravenous erythromycin should generally be avoided because of the possible additive effects on QT interval prolongation. 

A single-dose study in 8 healthy subjeets found that the AUC and serum levels of talinolol 50 mg were inereased by 51% and 26%, respectively, by erythromycin 2 g. It was suggested that the increased bioavailability of talinolol was due to inereased intestinal absorption caused by the inhibition of P-glycoprotein by erythromycin. ... 

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