Tailoring thin films for implant-specific applications

Steele, J.S.C. Loo, S.S. Venkatraman Nanyang Technological University, Singapore 

Thin Film Coatings for Biomaterials and Biomedical Applications. http //dx.doi.org/10.1016 978 l-78242-453-6.00003-l 

Thin Film Coatings for Biomaterials and Biomedical Applications 

for example, the hydrophobic drug paclitaxel, a powerful drug employed in antitumour and heart disease therapies. Paclitaxel is not fluorescent, but fluorescent analogues exist toward various life science protocols in which minute quantities suffice. In the amounts required for encapsulafion into thin films and subsequent drug release protocols, they are prohibitively expensive. The next best method is to employ a fluorescent economical mimic of the hydrophobic drug of interest to narrow release formulations that fit the delivery profile desired. Once the formulations are focused, the more laborious HPLC quantitation procedures can be verified with the original dmg of interest. 

Thin films specified for medical applications often go through many rounds of optimization, considering a generic film constituent of one or more polymer matrices, 

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Tailoring thin films for implant-specific applications... 

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