TAG Storage and Mobilization

Tab. 11.1 Natural and synthetic ligands known to affect TAG storage and/or mobilization in WAT via receptor-mediated mechanisms. Meanwhile, the adipocyte has gained the status of an endocrine cell with the discovery of regulated production of several secreted products of various nature (e.g. lipid metabolites, cytokines and other proteins) that are involved in autocrine, paracrine and endocrine effects on TAG storage and mobilization. Adapted from Ref. [559] with modifications.

Fig. 11.4 Hypothetical model for integration of the major mechanisms of TAG storage and mobilization (1) conversion of fibroblasts/ preadipocytes into adipocytes, (2) biogenesis of forming LD at the ER membrane, (3) fusion of smaller LD to mature LD, (4) translocation of HSL from the cytosol to the surface of LD, (5) disassembly and reorganization at...

The relatively mild phenotype of these mice suggests a minor role of ASP in TAG storage and mobilization control or the existence of compensatory mechanisms rescuing part of the physiological function of ASP. 

Fig. n.2 Schematic model forthe main signaling and metabolic pathways coupling hormonal stimuli and NEFA to (regulated) TAG synthesis, storage and mobilization in adipo-... 

Tab. 11.2 Differences in the regulation of TAG mobilization and storage between fat cells from visceral (vAT) and subcutaneous adipose tissue (scAT). The extent of some of these differences depends on the adipocyte hyperplasie (total fat mass) and hypertrophy as well as on the sex.

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